河豚毒素

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产品名称：河豚毒素
产品型号：M317840
产品价格：2
所属类别：仪器仪表 > 其他专用仪器仪表
发布时间：2017-04-10
已获点击：516

详细说明

河豚毒素 型号:1mg

库号：M317840

Tetrodotoxin（Na+ channels Inhibitor）
DESCRIPTION：
Tetrodotoxin (Fugu Toxin, TTX) is an orally active, potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels. Binding of Tetrodotoxin to voltage gated sodium channel results from the interaction between the positively charged guanidine group on the Tetrodotoxin with the negatively charged carboxylate groups on the side chains in the mouth of the sodium channel. Tetrodotoxin binding prevents diffusion of sodium ions through the sodium channels. This in turn prevents depolarization and propagation of action potentials in nerve cells leading to the loss of sensation [1]. In mammals, the physiological effects of Tetrodotoxin differ among various excitable tissues depending on the Voltage-Gated Sodium Channels isoforms expressed in their cells. Tetrodotoxin-sensitive Voltage-Gated Sodium Channels have been implicated in a number of chronic pain conditions. Tetrodotoxin has been extensively used in numerous laboratories to characterize the role of Voltage-Gated Sodium Channels in normal physiology and in disease and their involvement in the molecular mechanisms

东方化玻(北京)科技有限公司

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